The concert is being staged to promote their joint jazz album Cheek to Cheek.
Yesterday rumours surfaced suggesting that Lady Gaga would record a video clip in Brussels.
Record company Universal applied for the necessary permission two weeks ago.
Now it has emerged that Lady Gaga will perform with Tony Bennett in a bid to promote their album of jazz classics.
The concert starts at 10:30 pm and will be recorded for broadcast worldwide later this year.
Customers of mobile phone operator Mobistar can take part in a competition to win a free ticket to the concert.
City cabinet member for the City of Brussels, Philippe Close: "This event will put Brussels and the market square in the spotlight in an incredible way."
Flandersnews.be / Expatica